Table 3.
Association of biomarker/damage score and age with time to death caused by renal disease in dogs from multivariate Cox survival models. The unit increase for each biomarker/damage score and age is depicted in parentheses in the first column. Each row depicts a separate survival model that includes 2 covariables (biomarker or damage score and age)
| N | HR for Biomarker/Damage Score | HR for Age | |||
|---|---|---|---|---|---|
| HR (95% CI) | P Value | HR (95% CI) | P Value | ||
| Biomarker + Age (1 year) | |||||
| SCr (1 mg/dL) | 82 | 1.40 (1.26–1.56) | <.001 | 1.10 (0.99–1.22) | .072 |
| IgM_FE (0.01%) | 66 | 1.45 (1.25–1.69) | <.001 | 1.15 (1.00–1.32) | .047 |
| uRBP/c (10 μg/mg) | 83 | 1.07 (1.03–1.10) | <.001 | 1.07 (0.98–1.18) | .14 |
| RBP_FE (1%) | 66 | 1.17 (1.07–1.28) | .001 | 1.16 (1.01–1.33) | .034 |
| NGAL_FE (25%) | 59 | 1.23 (1.07–1.41) | .003 | 1.09 (0.95–1.25) | .20 |
| IgG_FE (1%) | 66 | 1.47 (1.11–1.95) | .007 | 1.15 (1.00–1.31) | .044 |
| Damage score + Age (1 year) | |||||
| TI damage score (1 score point) | 82 | 2.60 (1.59–4.24) | <.001 | 1.07 (0.97–1.17) | .17 |
| LM glomerular damage score (1 score point) | 82 | 1.60 (1.12–2.29) | .009 | 1.08 (0.98–1.20) | .13 |
| TEM glomerular damage score (0/1 versus 2/3) | 72 | 2.58 (1.03–6.44) | .042 | 1.05 (0.94–1.18) | .37 |
HR, hazard ratio; CI, confidence interval; LM, light microscopy; TEM, transmission electron microscopy; TI, tubulointerstitial; SCr, serum creatinine; IgG_FE, fractional excretion of immunoglobulin G; IgM_FE, fractional excretion of immunoglobulin M; uRBP/c, urine retinol binding protein/urine creatinine; RBP_FE, fractional excretion of retinol binding protein; NGAL_FE, fractional excretion of neutrophil gelatinase‐associated lipocalin.