Table 3.
Sensitivity, specificity, and Youden index of different cutoff points of 4 echocardiographic indices of PH for the prediction of peak tricuspid regurgitation systolic pressure gradient (TRPG) >36 mmHg in 69 dogs
| Variable | AUC | 95% CI | P | Cutoff | Sensitivity | Specificity | Youden Index |
|---|---|---|---|---|---|---|---|
| MPA:Ao | 0.89 | 0.81–0.97 | <.0001 | >0.85 | 1.00 | 0.14 | 0.14 |
| >0.98 | 0.85 | 0.86 | 0.71 | ||||
| >1.10 | 0.55 | 1.00 | 0.55 | ||||
| RPAD index (%) | 0.88 | 0.80–0.96 | <.0001 | <44.2 | 1.00 | 0.23 | 0.23 |
| <34.6 | 0.74 | 0.91 | 0.65 | ||||
| <27.7 | 0.53 | 1.00 | 0.53 | ||||
| AT (ms) | 0.88 | 0.80–0.97 | <.0001 | <102.3 | 1.00 | 0.14 | 0.14 |
| <72.1 | 0.89 | 0.77 | 0.67 | ||||
| <50.7 | 0.43 | 1.00 | 0.43 | ||||
| AT:ET | 0.80 | 0.69–0.90 | <.0001 | <0.56 | 1.00 | 0.05 | 0.05 |
| <0.38 | 0.79 | 0.68 | 0.47 | ||||
| <0.31 | 0.45 | 1.00 | 0.45 |
AUC, area under receiver operating characteristic curve; PH, pulmonary hypertension; See Table 1 for remainder for the remainder of the key. Bolded values represent a clinically relevant cutoff, with the least amount of overlap between groups (optimal combination of sensitivity and specificity and highest Youden index).