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. 2016 Apr 4;7:135–145. doi: 10.1016/j.ebiom.2016.04.002

Fig. 5.

Fig. 5.

Hepatic LRP1 deficiency leads to diet-Induced dyslipidemia. WT and hLRP1KO mice were maintained on 16 weeks of chow diet or HFD. Plasma was collected after overnight fast. (a) Plasma triglyceride, cholesterol and NEFA levels (n = 11–17 for each group, data are mean ± SEM, *P < 0.05; **P < 0.01). (b) Representative Western blot (left panel) and quantitative analysis (right panel) of plasma apolipoprotein levels (n = 5 for each group, data are mean ± SEM, ⁎⁎P < 0.01). (c) Pooled plasma from 5 mice from each group was analyzed by FPLC for lipoprotein cholesterol (left) and triglyceride (right) content. (d) Equal aliquots (0.3 mL) from three consecutive FPLC fractions were pooled for Western blot analysis of apoB100, apoB48, apoE and apoAI levels in the different fractions.