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. 2016 Apr 4;7:135–145. doi: 10.1016/j.ebiom.2016.04.002

Fig. S3.

Fig. S3.

Hepatic LRP1 deficiency suppressed insulin signaling in adipose tissue but not in skeletal muscle. (a) Representative paraffin-embedded sections of epididymal WAT from chow-fed (upper panel) or HFD-fed (lower panel) WT and hLRP1KO mice were stained with haematoxylin & eosin. Scale bar = 50 μm. (b) Adipocyte area in H&E paraffin sections of epididymal WAT were quantified for each group (n = 5–10 for each group, **P < 0.01, mean ± SEM). (c) Representative western blot and quantification of insulin-stimulated phosphorylated-AKT, total AKT and GLUT4 in adipose tissue of WT mice and hLRP1KO mice. Calnexin was used as loading control (n = 5 for each group, *P < 0.05, mean ± SEM). (d) Representative western blot and quantification of insulin-stimulated phosphorylation of AKT, total AKT and GLUT4 in skeletal muscle of WT mice and hLRP1KO mice. Calnexin was used as loading control.