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. 2016 May 30;38(6):340–351. doi: 10.1111/pim.12322

Figure 6.

Figure 6

SMAs 11a and 12b inhibit influx of eosinophils into the lungs of mice undergoing CR‐induced airway inflammation. BALB/c mice undergoing CR‐induced airway hyper‐responsiveness (‘none’) were treated with SMAs 11a or 12b 1 h prior to each exposure to CR. (a) total cell count in BALF collected at sacrifice. Influx of alveolar macrophages (b: Ly6C‐Ly6G‐ CD3‐ CD19‐ CD11c+F4/80+), eosinophils (c: SSC highSiglecF+) and neutrophils (d: SSC highLy6G+) is shown as total number of cells in BALF. Data are pooled from 3 independent experiments. Symbols on each graph are representative of individual mice in the indicated groups. One of the control mice was identified as an outlier by the GraphPad Prism ROUT test in all of these cell types and hence was excluded from the statistical analyses where *P < 0·05 and **P < 0·01 and the P‐value is indicated in comparison with the control (no CR exposure) mice.