Figure 7.
Effect of ES‐62 SMAs on lymphocyte cytokine production. DLN cells (3 × 105 lymphocytes) were taken from control, CR‐ or CR‐SMA‐treated animals and cultured ex vivo with medium alone or CR (50 μg) for 72 h. Cell culture supernatants were removed, and IFN‐γ (a) and IL‐4 levels measured by ELISA. The data presented are pooled from 3 independent experiments and *P < 0·05 and ***P < 0·001 are for untreated CR‐exposed mice (none) vs. SMA‐treated CR‐exposed mice and ###P < 0·001 for control (no CR exposure) vs. CR‐exposed (none) mice.