Table I.
Demographic and Clinical Characteristics for the Overall Cohort and the Cohort Completing fMRI
| MSLT (N = 62) | +fMRI (n = 29) | −fMRI (n = 10) | pa | |
|---|---|---|---|---|
| % | % | % | % | |
| Sex | 0.651 | |||
| Male | 51.6 | 51.7 | 60.0 | |
| Female | 48.4 | 48.3 | 40.0 | |
| Hypothalamic involvement | 0.242 | |||
| Grade 0 | 12.9 | 17.2 | 20.0 | |
| Grade 1 | 30.6 | 37.9 | 10.0 | |
| Grade 2 | 56.5 | 44.8 | 70.0 | |
| Surgical procedure | 0.196 | |||
| Catheter only – craniotomy | 4.8 | 10.3 | 10.0 | |
| Catheter only – burr hole | 12.9 | 41.4 | 20.0 | |
| Resection – craniotomy | 51.6 | 24.1 | 50.0 | |
| Resection – transphenoidal | 17.7 | 24.1 | 20.0 | |
| None | 12.9 | |||
| Laterality | 0.153 | |||
| Left | 12.9 | 4.5 | 30.0 | |
| Right | 51.6 | 37.9 | 50.0 | |
| Midline | 17.7 | 24.1 | 20.0 | |
| Bifrontal | 4.8 | 10.3 | ||
| CSF diversion | 0.951 | |||
| Yes | 29 | 69.0 | 70.0 | |
| No | 71 | 31.0 | 30.0 | |
| Diabetes insipidus | 0.777 | |||
| Yes | 54.8 | 55.2 | 50.0 | |
| No | 45.2 | 44.8 | 50.0 | |
| Visual acuity (right) | 0.314 | |||
| No deficits | 67.7 | 79.3 | 60.0 | |
| Reduced, no functional impairment | 16.1 | 13.8 | 40.0 | |
| Reduced, functional impairment | 11.3 | 3.4 | ||
| Blind | 4.8 | 3.4 | ||
| Visual acuity (left) | 0.484 | |||
| No deficits | 69.4 | 86.2 | 70.0 | |
| Reduced, no functional impairment | 9.7 | 6.9 | 20.0 | |
| Reduced, functional impairment | 14.5 | 3.4 | ||
| Blind | 6.5 | 3.4 | 10.0 | |
| Excessive daytime sleepiness | 0.045 | |||
| Yes | 75.8 | 69.0 | 100.0 | |
| No | 24.2 | 31.0 | . | |
| Epworth Sleepiness Scale – Parentb | 0.908 | |||
| Impaired (total score >10) | 40.4 | 37.9 | 60.0 | |
| Unimpaired (total score ≤9) | 59.6 | 62.1 | 40.0 | |
| M ± SD | M ± SD | M ± SD | ||
| Age at exam | 11.0 ± 4.0 | 13.1 ± 3.6 | 12.1 ± 3.1 | 0.449 |
| Full-Scale IQ | 99.5 ± 20.4 | 105.0 ± 14.7 | 93.3 ± 14.4 | 0.037 |
| Total number of surgeries | 1.4 ± 1.0 | 1.0 ± 0.8 | 1.6 ± 0.8 | 0.044 |
| MSLT mean sleep-onset latency | 8.0 ± 5.8 | 9.6 ± 5.9 | 5.4 ± 5.0 | 0.053 |
| MSLT total number of SOREMP | 1.2 ± 1.4 | 0.7 ± 1.1 | 2.0 ± 1.6 | 0.006 |
Note. MSLT = Multiple Sleep Latency Test; +fMRI = eligible and completed fMRI exam; −fMRI = eligible and did not complete fMRI exam; CSF = cerebrospinal fluid; SOREMP = sleep-onset REM periods. Hypothlamic involvement was assessed before surgical intervention. Clinical and treatment variables reference procedures completed before study baseline. Surgical variables reference the most extensive procedure completed before study baseline.
aTwo-sided p-value from comparisons between + fMRI and −fMRI cohorts.
bN = 52.