Table 2.

Comparative features of sites of infection, rates of ICU admission, and organ failure among severely septic women with and without pregnancy-associated hospitalizations.

Variable	PASS* (n=449)	NPSS** (n=1874)	p
Sites of infection, n (%)#
Respiratory	102 (22.7)	629 (33.6)	<0.0001
Urinary	152 (33.9)	750 (40.0)	0.0185
Genital	200 (44.5)	3 (0.2)	<0.0001
Abdominal	37 (8.2)	260 (13.9)	0.0017
Endocarditis	1 (0.2)	33 (1.8)	0.0265
Skin and soft tissue	1 (0.2)	21 (1.1)	0.1354
Device-related	13 (2.9)	143 (7.6)	0.0005
Other##	6 (1.3)	58 (3.1)	0.0595
Admission to ICU, n (%)	382 (85.1)	1555 (83)	0.3157
Number of failing organs
(median [IQR])	1 (1–2)	2 (1–3)	0.0005
≥3 Organ failures, n (%)	74 (16.5)	503 (26.8)	<0.0001
Type of organ failure###, n (%)
Respiratory	244 (54.3)	931 (49.7)	0.0850
Cardiovascular	220 (49.0)	1025 (54.7)	0.0339
Renal	82 (18.3)	607 (32.4)	<0.0001
Hematological	99 (22.0)	441 (23.5)	0.5444
Metabolic	83 (18.5)	369 (19.7)	0.6080
Neurological	11 (2.4)	166 (8.9)	<0.0001

^*PASS – pregnancy-associated severe sepsis;

^**NPSS – severe sepsis not associated with pregnancy;

^#The total rates exceed 100% due to presence of more than one site of infection among severe sepsis hospitalizations;

^##Other infections included bloodstream (3) and central nervous system (3) for PASS, and bloodstream (20) and central nervous system (39) for NPSS;

^###No hepatic failure was reported in either group.