Table 3. Association between response and methylation/expression of VEGFA, VEGFB and VEGFC.
| TCGA cohort (HumanMethylation27) (CR+PR: 174 vs. SD+PD 39) |
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|---|---|---|---|---|---|---|
| Genes | Methylation level$ | OR | 95% CI | p value | # PR+CR | # PD+SD |
| VEGFA | High methylation | 1.61 | (0.66, 3.92) | 0.29 | 24 | 8 |
| Low methylation | 1 | 150 | 31 | |||
| VEGFB | High methylation | 2.13 | (0.97, 4.68) | 0.059+ | 30 | 12 |
| Low methylation | 1 | 144 | 27 | |||
| VEGFC | High methylation | 1.03 | (0.43, 2.43) | 0.955 | 35 | 8 |
| Low methylation | 1 | 139 | 31 | |||
| TCGA cohort (Affymetrix HGU133A) (CR+PR: 174 vs. SD+PD 39) |
||||||
| Genes | Expression level$$ | OR | 95% CI | p value | # PR+CR | # PD+SD |
| VEGFA | High expression | 1.15 | (0.48, 2.72) | 0.759 | 32 | 8 |
| Low expression | 1 | 142 | 31 | |||
| VEGFB | High expression | 2.57 | (1.22, 5.43) | 0.013* | 34 | 15 |
| Low expression | 1 | 140 | 24 | |||
| VEGFC | High expression | 2.2 | (0.73, 6.61) | 0.159 | 139 | 35 |
| Low expression | 1 | 35 | 4 | |||
$
20% of the patients with highest level of methylation were categorised in the ‘high methylation group’, otherwise, they were include in the ‘low methylation group’
$$
If expression was positively correlated with methylation, 20% of the patients with highest level of expression were categorised in the “high expression group”, otherwise, they were included in the “low expression group”. If expression was reversely correlated with expression, 20% of the patients with lowest level of expression were categorised in the “low expression group”, otherwise, they were in the “high expression group”