Table.

Clinical and Vascular Characteristics

	Nondiabetic (n=43)	Diabetic (n=42)
Clinical Characteristics
Age, y	50±9	54±12
Female sex, %	42	60
Postmenopausal,% women	50	72
Black race, %	47	69*
Weight, kg	85±18	105±24*
Height, cm	174±9	169±14
Body mass index, kg/m2	28.3±5.1	36.3±8*
Total cholesterol, mg/dL	197±40	184±44
LDL cholesterol, mg/dL	122±64	114±38
HDL cholesterol, mg/dL	54±16	45±10*
Triglycerides, mg/dL	105±59	121±50*
Fasting glucose, mg/dL	88±10	150±57*
Hemoglobin A1c, %	5.3±1.4	7.5±1.9*
Systolic blood pressure, mm Hg	122±15	132±26*
Diastolic blood pressure, mm Hg	75±11	77±16
Ankle-brachial index	1.14±0.1	1.09±0.1*
Antiplatelet therapy, %	9	42*
Lipid lowering therapy, %	12	45*
ACE inhibitor or ARB therapy, %	3	50*
Metformin, %	0	74*
Sulfonylureas, %	0	12*
Insulin therapy, %	0	48*
Peripheral Artery Disease, %	0	7
Coronary Artery Disease, %	0	7
Prior Stroke, %	2	7
Vascular function
Baseline diameter, mm	4.12±0.77	4.23±0.67
Baseline flow, mL/min	107±85	125±81
Hyperemic flow, mL/min	953±435	762±389
Flow-mediated dilation, %	9.9±4.1	6.2±3.3*
Nitroglycerin-mediated dilation	15.1±8.5	9.23±8.3*
Baseline flow velocity	12±6	14±6
Hyperemic flow velocity	116±30	88±35*

Data are expressed as mean±SD. LDL indicates low-density lipoprotein; HDL, high density lipoprotein; ACE, angiotensin-converting enzyme: ARB-angiotensin receptor blocker: PAD, peripheral artery disease: ABI, Ankle-branchial index; CAD, coronary artery disease; CAD, Cardiovascular disease.

^*P<0.05