Table 3. Inhibitory KHKC Activity of Candidate Phytochemicals.
| Phytochemical | Genus | Species | Phytochemical Plate | KHKC Inhibition (%) | KHKC IC50 (μM) | |
|---|---|---|---|---|---|---|
| Plate ID | Well | |||||
| Methoxy isobavachalcone | Psoralea | corylifolia | AnalytiCon Plate #4 | C9 | 70.8 | 0.2 |
| Osthole | Angelica | archangelica | AnalytiCon Plate #2 | G10 | 93.4 | 0.7 |
| Cratoxyarborenone E | Cratoxylum | prunifolium | AnalytiCon Plate #2 | C8 | 61.7 | 1.0 |
| α-/γ-Mangostin | Cratoxylum | prunifolium | AnalytiCon Plate #4 | F2 | 90.4 | 1.5 |
| 3,4',5,7-THMethoxy3'-O-B-D-Xylopyranoside | Nymphaea | lotus | AnalytiCon Plate #1 | D10 | 63.3 | 3.5 |
| Isobavachalcone | Psoralea | corylifolia | AnalytiCon Plate #10 | B11 | 44.2 | 5.7 |
| Osthenol | Angelica | archangelica | AnalytiCon Plate #5 | G10 | 74.1 | 7.8 |
| Oroxylin A | Scutellaria | baicalensis | AnalytiCon Plate #3 | E1 | 42.1 | 8.2 |
| 5,7-Dimethoxy-8-prenylcoumarin | Diospyros | attenuata | AnalytiCon Plate #1 | G7 | 70.4 | 10.3 |
| Polyketide type molecule | Myrica | cerifera | AnalytiCon Plate #2 | B8 | 61.2 | 11.3 |
| Apigenin 7-glucuronide | Andrographis | paniculata | AnalytiCon Plate #4 | F3 | 53.1 | 16.1 |
| Apiin | Petroselinum | crispum | AnalytiCon Plate #6 | E1 | 47.0 | 21.5 |
| Flavaspidic acid AB | Pteris | wallichiana | AnalytiCon Plate #2 | F8 | 48.7 | 29.5 |
| Mulberrin | Morus | alba | AnalytiCon Plate #3 | D7 | 61.2 | 31.2 |
| Swietenocoumarin B | Chloroxylon | swietenia | AnalytiCon Plate #13 | G6 | 62.5 | 58.4 |
AnalytiCon: Phytochemicals from MEGx library (AnalytiCon Discovery GmbH, Potsdam, Germany) were selected and purchased by Amway Corp. IC50: half maximal inhibitory concentration. KHKC: ketohexokinase isoform C.