Table 1. Clinical features of 20 patients with MLC.

Pt	Sex	Age onset	Age*	Age	HC (cm)	HCtr	IS	IW	WE	G*	PS	EPS	Ata-xia	FH	MRI
															Age	WMA	Cysts
1	F	0m	1y	9y2m	55	3m	7m	1y6m	14m	Ⅱ	-	-	-	-	1y	+	+
2	M	5m	5y3m	13y	54.5	3m	8m	1y6m	1y	Ⅰ	-	+	-	+	5y	+	+
3	M	4m	3y4m	10y7m	55.5	3m	12m	1y6m	1y	Ⅰ	+	-	+	-	3y4m	+	+
4	M	0m	3y7m	10y1m	57.5	3m	8m	1y5m	3y	Ⅰ	-	-	-	-	3y	+	+
5	F	2m	10m9d	5y9m	50.5	3m	6m	2y	11m	Ⅰ	-	-	-	-	10m	+	+
6	F	0m	1y9m	5y7m	52	3m	7m	1y8m	1y	Ⅰ	-	-	-	-	1y9m	+	+
7	M	5m	2y1m	4y6m	57	3m	6m	2y	1y7m	Ⅰ	-	+	-	-	1y8m	+	+
8	M	2m	1y5m	3y2m	56	3m	7m	1y3m	1y	Ⅰ	-	+	-	-	1y	+	+
9	F	5m	1y4m	3y	52.5	3m	7m	3y	1y	Ⅰ	-	+	-	+	1y4m	+	+
10	F	5m	1y4m	3y	/	3m	7m	3y	1y	Ⅰ	-	+	-	+	1y4m	+	+
11	M	0m	11m	1y5m	51.5	3m	6m	1y3m	11m	Ⅰ	-	-	-	-	5m, 8m	+	+
12	M	2m	1y8m	2y1m	55	2m	8m	1y8m	8m	Ⅱ	-	+	-	-	1y4m	+	+
13	M	0m	2y2m	4y1m	57	3m	11m	1y6m	1y	Ⅰ	+	-	+	-	1y8m	+	+
14	F	0m	3y6m	5y8m	60	3m	7m	1y6m	10m	Ⅱ	+	-	-	-	3y2m	+	+
15	F	2m	9m	2y5m	50	NA	7m	1y8m	1y	Ⅰ	-	-	-	-	9m	+	+
16	M	5m	9m	6y3m	50	3m	7m	NA	NA	Ⅰ	-	+	-	-	9m	+	+
17	M	0m	1y5m	7y6m	53	7m	8m	1y1m	13m	Ⅰ	-	-	-	+	1y3m	+	+
18	M	4m	9m3d	4y3m	50	4m	7m	1y9m	1y6m	Ⅰ	-	+	-	-	8m	+	+
19	F	4m	5y	12y6m	55	4m	8m	2y	1y2m	Ⅱ	-	-	-	-	5y	+	+
20	M	0m	10.5m	5y3m	52	4m	10m	1y6m	2y	Ⅰ	+	-	-	-	10.5m	+	+

Abbreviations: F, female; Age^onset, onset age; Age*, age at first diagnosis; Age, age at the third follow-up study; M, male; y, year; m, month; HC, Head circumference(cm); HCtr, Head Control; IS, independent sitting; IW, independent walking; WE, word expression; G*, gross motor function classification system at first diagnosis; PS, pyramidal signs; EPS, extralpyramidal signs; FH, family history; MRI, magnetic resonance imaging; WMA, white matter abnormal signals;+,positive;-,negative