Table 3.
Cox regression analysis of the clinicopathological parameters in colon cancer patients
| Parameters | Coefficient | Hazard ratio (HR) | 95% CI for HR | P-value |
|---|---|---|---|---|
| Age | −0.004 | 0.996 | 0.979–1.014 | 0.665 |
| Sex | −0.235 | 0.791 | 0.528–1.184 | 0.254 |
| Distance metastasis | 1.656 | 5.236 | 2.128–12.880 | <0.001 |
| Lymph nodes metastasis | 0.463 | 1.589 | 1.028–2.455 | 0.037 |
| TNM stage | 0.677 | 1.968 | 0.776–4.993 | 0.154 |
| Pathology grading | 0.332 | 1.394 | 0.956–2.032 | 0.084 |
| SP expression | 2.922 | 18.584 | 7.069–48.858 | <0.001 |
| NK1R expression | −0.351 | 0.704 | 0.379–1.309 | 0.268 |
Abbreviations: SP, substance P; NK1R, neurokinin-1 receptor; TNM, tumor node metastasis.