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. 2016 Jun 16;9:3579–3588. doi: 10.2147/OTT.S105470

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© 2016 Zhang et al. This work is published and licensed by Dove Medical Press Limited

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PTEN overexpression abrogates the prometastatic effects of miR-92a mimics on 6-10B cells.

Notes: (A) PTEN expression vector significantly increased the PTEN expression and decreased p-AKT expression in miR-92a overexpressing 6-10B cells; n=3 independent repeats with similar results; *P<0.05. (B) Restoration of PTEN in miR-92a overexpressing 6-10B cells abrogated the effects of miR-92a mimics on cell migration and invasion; n=3 repeats with similar results; *P<0.05.

Abbreviations: GAPDH, glyceraldehyde 3-phosphate dehydrogenase; miR-92a, microRNA-92a; PTEN, phosphatase and tensin homolog.