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. 2016 Jun 16;11:2883–2900. doi: 10.2147/IJN.S106346

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© 2016 Lee et al. This work is published and licensed by Dove Medical Press Limited

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Biodistribution of Cu from Cu NPs and Cu ions.

Notes: Cu levels in (A) liver, (B) kidney, (C) spleen, (D) heart, (E) lung, and (F) brain in the Cu NP- and Cu ion-treated rats are determined at 0 hour (control), 12 hours, 24 hours, 48 hours, 72 hours, 1 week, 2 weeks, and 4 weeks after a single oral dose of 500 mg/kg each. Values are presented as mean ± SD (n=3). *P<0.05, **P<0.01 vs vehicle control. Cu ions, copper(II) chloride.

Abbreviations: Cu NPs, copper nanoparticles; SD, standard deviation.