Table S1.
Absolute and relative organ weights in rats treated with Cu NPs
| Items | Cu NPs (mg/kg)
|
||||
|---|---|---|---|---|---|
| 0 | 312 | 625 | 1,250 | 2,500 | |
| Male | |||||
| Number of rats | 5 | 5 | 5 | 5 | – |
| Body weight at term | 412.6±6.01 | 406.7±16.31 | 403.0±26.41 | 375.0±30.99 | – |
| Brain (g) | 1.90±0.021 | 1.87±0.022 | 1.88±0.079 | 1.82±0.081 | – |
| Per bw (%) | 0.45±0.003 | 0.45±0.018 | 0.44±0.030 | 0.52±0.080 | – |
| Liver (g) | 14.94±0.731 | 14.91±1.633 | 15.20±0.982 | 1.33±1.327 | – |
| Per bw (%) | 3.61±0.232 | 3.58±0.468 | 3.65±0.177 | 4.07±0.283* | – |
| Spleen (g) | 0.86±0.042 | 0.83±0.040 | 0.88±0.033 | 0.76±0.056 | – |
| Per bw (%) | 0.21±0.016 | 0.21±0.018 | 0.21±0.020 | 0.21±0.024 | – |
| Heart (g) | 1.20±0.071 | 1.19±0.048 | 1.25±0.080 | 1.06±0.103* | – |
| Per bw (%) | 0.28±0.023 | 0.29±0.018 | 0.30±0.017 | 0.30±0.021 | – |
| Thymus (g) | 0.59±0.071 | 0.58±0.026 | 0.56±0.083 | 0.42±0.173* | – |
| Per bw (%) | 0.13±0.028 | 0.13±0.014 | 0.13±0.017 | 0.12±0.039 | – |
| Lung (g) | 1.51±0.163 | 1.52±0.118 | 1.63±0.055 | 1.43±0.133 | – |
| Per bw (%) | 0.35±0.026 | 0.37±0.033 | 0.38±0.025 | 0.41±0.036* | – |
| Kidneys (g) | 2.53±0.014 | 2.55±0.029 | 2.90±0.193 | 3.13±0.634* | – |
| Per bw (%) | 0.61±0.005 | 0.62±0.010 | 0.69±0.029 | 0.86±0.165** | – |
| Adrenal glands (g) | 0.048±0.0007 | 0.049±0.0012 | 0.050±0.0048 | 0.047±0.0100 | – |
| Per bw (%) | 0.012±0.0013 | 0.012±0.0016 | 0.012±0.0016 | 0.014±0.0047 | – |
| Testes (g) | 3.45±0.269 | 3.40±0.099 | 3.41±0.248 | 3.28±0.291 | – |
| Per bw (%) | 0.84±0.031 | 0.82±0.023 | 0.81±0.062 | 0.93±0.071* | – |
| Prostate (g) | 0.63±0.048 | 0.65±0.034 | 0.74±0.135 | 0.72±0.282 | – |
| Per bw (%) | 0.15±0.022 | 0.16±0.016 | 0.17±0.024 | 0.20±0.072 | – |
| Seminal vesicles (g) | 2.06±0.276 | 2.01±0.198 | 1.68±0.114 | 1.44±0.458* | – |
| Per bw (%) | 0.50±0.035 | 0.48±0.022 | 0.40±0.008* | 0.40±0.095* | – |
| Epididymides (g) | 1.06±0.092 | 1.05±0.047 | 1.01±0.068 | 0.89±0.107* | – |
| Per bw (%) | 0.26±0.011 | 0.25±0.010 | 0.24±0.020 | 0.25±0.019 | – |
| Female | |||||
| Number of rats | 5 | 5 | 5 | 5 | 2 |
| Body weight at term | 257.4±13.18 | 255.3±14.71 | 255.7±13.23 | 244.2±11.17 | 235.6±11.90 |
| Brain (g) | 1.69±0.064 | 1.78±0.069 | 1.83±0.095 | 1.76±0.160 | 1.77±0.015 |
| Per bw (%) | 0.72±0.032 | 0.70±0.081 | 0.72±0.100 | 0.72±0.057 | 0.76±0.110 |
| Liver (g) | 8.27±0.898 | 8.46±0.912 | 8.65±1.360 | 8.52±0.901 | 8.20±1.262 |
| Per bw (%) | 3.21±0.389 | 3.31±0.214 | 3.37±0.198 | 3.48±0.150 | 3.47±0.086 |
| Spleen (g) | 0.69±0.021 | 0.69±0.019 | 0.68±0.097 | 0.67±0.082 | 0.51±0.067 |
| Per bw (%) | 0.27±0.012 | 0.27±0.017 | 0.26±0.016 | 0.27±0.045 | 0.22±0.050 |
| Heart (g) | 0.78±0.078 | 0.80±0.063 | 0.85±0.050 | 0.85±0.052 | 0.80±0.031 |
| Per bw (%) | 0.30±0.034 | 0.31±0.027 | 0.33±0.024 | 0.35±0.0142 | 0.34±0.041 |
| Thymus (g) | 0.35±0.021 | 0.35±0.028 | 0.38±0.062 | 0.35±0.067 | 0.24±0.042** |
| Per bw (%) | 0.15±0.010 | 0.15±0.009 | 0.16±0.007 | 0.17±0.028 | 0.11±0.037* |
| Lung (g) | 1.30±0.212 | 1.31±0.164 | 1.33±0.297 | 1.22±0.101 | 1.20±0.067 |
| Per bw (%) | 0.51±0.089 | 0.51±0.047 | 0.51±0.065 | 0.50±0.034 | 0.52±0.085 |
| Kidneys (g) | 1.61±0.071 | 1.68±0.131 | 1.60±0.126 | 1.64±0.152 | 1.68±0.158 |
| Per bw (%) | 0.63±0.035 | 0.67±0.021 | 0.63±0.017 | 0.67±0.051 | 0.72±0.079* |
| Adrenal glands (g) | 0.064±0.0190 | 0.064±0.0071 | 0.061±0.0041 | 0.064±0.0049 | 0.071±0.0075 |
| Per bw (%) | 0.025±0.0071 | 0.024±0.0022 | 0.024±0.0027 | 0.026±0.0011 | 0.031±0.0070 |
| Ovaries (g) | 0.099±0.0253 | 0.097±0.0103 | 0.078±0.0077 | 0.102±0.0112 | 0.086±0.0191 |
| Per bw (%) | 0.038±0.0094 | 0.037±0.0043 | 0.031±0.0055 | 0.042±0.0065 | 0.036±0.0039 |
Notes: Values are presented as mean ± SD. “–” indicates no record of organ weights.
*
P<0.05,
**
P<0.01 vs vehicle control.
Abbreviations: Cu NPs, copper nanoparticles; bw, body weight; SD, standard deviation.