Table 3.
Comparison of cardiopulmonary exercise test and 123I-MIBG scintigraphic variables after treatment with nebivolol
| Intervention | Control | |||||
|---|---|---|---|---|---|---|
| Variable | Baseline | 3 months | p | Baseline | 3 months | p |
| ISBP mmHg | 149(143.5-171) | 135(125-151) | 0.016 | 162 (132 -170) | 148 (132-160) | 0.213 |
| IDBP mmHg | 91 (80.5-106.5) | 91(87.5-107.5) | 0.179 | 90 (78 - 104) | 100 (70-102) | 0.682 |
| IHR bpm | 78 (65.5 - 84) | 64.5(57.5-75.5) | 0.028 | 66 (55 - 72) | 64 (61-77) | 0.656 |
| PSBP mmHg | 235(216.5-249) | 198(191-220.5) | 0.001 | 230 (216 -238) | 222 (210-240) | 0.683 |
| PDBP mmHg | 111(102.5-120) | 113 (91.5-118) | 0.441 | 104 (82 - 110) | 110(78-120) | 0.24 |
| PHR bpm | 124.5(115-142) | 115(103.7-124) | 0.043 | 117 (104 -146) | 123(106-138) | 0.919 |
| SBPDE mmHg | 69 (52 - 102.5) | 69 (38-86) | 0.116 | 76 (52 - 96) | 72 (60-108) | 0.447 |
| CRI % | 60.1(43.5-81.5) | 51.5(32.9-70.5) | 0.124 | 58.7(40.7-91.3) | 65.2(40.2-89.2) | 0.929 |
| HRR 1st bpm | 6.5(4.75-12.75) | 14.5(6.7-22) | 0.025 | 18 (7 - 21) | 18 (11-29) | 0.285 |
| HRR 2° bpm | 15.5(13- 21.75) | 23.5(16-31.7) | 0.005 | 26 (19 -33) | 23 (14-41) | 0.54 |
| VO2 AT ml.(kgml)-1 | 10.89(7.9-12.5) | 10.5(7.8-13.6) | 0.917 | 10.6(7.8-14.2) | 9.8(5.9-13.5) | 0.169 |
| Percent O2 peak at AT % | 72.9(66.6-86.4) | 78.1(65.5-90.6) | 0.422 | 77.7(72.5-85.1) | 77.4(65.3-82) | 0.333 |
| R | 1.1(1.03 - 1.16) | 1.16(1.02-1.35) | 0.158 | 1.18(1.07-1.23) | 1.25(1.1-1.4) | 0.203 |
| Peak VO2 ml.(kgml)-1 | 14.07(10.7- 18) | 14.18(9.3-17.1) | 0.551 | 12.75(8.4-16.7) | 13.02(7.4-17.8) | 0.155 |
| VE/VCO2 slope | 22.73(20-26.6) | 21.7(19.3-28.8) | 0.363 | 23.3(22.5-26.9) | 22.5(20.6-27.4) | 0.999 |
| O2 pulse ml.(kgml)-1/bpm | 8.6(7.12 - 11.6) | 8,9(7.1-12.2) | 0.421 | 9 (6.6 - 10.8) | 8.1 (6.1-10.2) | 0.005 |
| Percent O2 pulse predicted % | 61.2(41.7-83.1) | 65.1(46.8-80.6) | 0.49 | 60.8(45.4-85.1) | 63.6(43.5-84.6) | 0.131 |
| H/M30min | 1.89(1.65-1.97) | 1.85(1.61-1.97) | 0.73 | 1.6 (1.56 - 1.8) | 1.63(1.47-1.77) | 0.398 |
| H/M 4 h | 1.77(1.57-1.94) | 1.68(1.58-1.88) | 0.263 | 1.58 (1.22 - 2) | 1.52(1.45-1.8) | 0.423 |
| WR(%) | 29.5(21.85-51) | 31(28.2-35) | 0.9 | 27 (14.3 - 30) | 30 (15 - 42) | 0.722 |
ISBP: initial systolic blood pressure; IDBP: initial diastolic blood pressure; IHR: initial heart rate; PSBP: systolic blood pressure at peak effort; PDBP: diastolic blood pressure at peak effort; PHR: heart rate at peak effort; SBPDE: systolic blood pressure variation during effort; CRI: chronotropic reserve index; HRR1st: heart rate variation at the first minute of recovery; HRR2nd: heart rate variation at the second minute of recovery; VO2: oxygen uptake; AT: anaerobic threshold; R: respiratory coefficient; VE/VCO2 slope: minute ventilation to carbon dioxide output slope; O2: oxygen; H/M30min: heart to mediastinum ratio 30 minutes after injection of the radiotracer (early); H/M4h: Heart to mediastinum ratio 4 hours after injection of the radiotracer (late); WR: washout rate.