Figure 2.

A proposed model of Akt2-mediated phosphorylation of Tmod3 in the regulation of cortical actin remodeling and GSV-PM fusion. In insulin-stimulated adipocytes, activated Akt2 functions as a signaling hub to activate a number of downstream effectors that are necessary for multiple steps of GLUT4 exocytosis. Release of G-actin from Tmod3 upon phosphorylation by Akt2 may provide a temporal and spatial supply of actin monomers to the local sites of exocytosis in order to facilitate the transient buildup of cortical actin at the periphery. The pairing of Tmod3 and Tm5NM1 may help define a specific population of actin filaments at the cell periphery to enable the process of GLUT4 vesicle fusion with the PM.