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. Author manuscript; available in PMC: 2017 Apr 21.
Published in final edited form as: Cell. 2016 Apr 7;165(3):704–714. doi: 10.1016/j.cell.2016.03.028

Figure 7. Schematic Summary of ECD Conformational Changes in NMDAR.

Figure 7

Shown are the conformational changes of the extracellular ATD and LBD layers associated with the transition from the apo state to the antagonist-bound state (right), the agonist-bound state (middle) and the agonist/Ro25-6981-bound (left). The bottom panel shows top-down views of various LBD conformations at different states. At present there is no structure for an apo-state and thus the schematic is grey.