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. Author manuscript; available in PMC: 2016 Jun 20.
Published in final edited form as: Neuron. 2014 Sep 11;84(1):214–226. doi: 10.1016/j.neuron.2014.08.019

Figure 5. Computational model I: Gain modulation of units outside of the inhibitory feedback loop does not reproduce the experimental effects of AGF microstimulation.

Figure 5

The AGF modulates the gain of OTid units in a space-specific manner. (A-C) Effects of aligned AGF stimulation. (A) Red ring: OTid unit whose gain is multiplicatively modified (as shown in inset) by aligned AGF microstimulation. Inset: Visual mnemonic illustrating multiplicative gain modulation of OTid responses by AGF microstimulation. Shown are schematic responses of an OTid unit to a single stimulus inside the RF, without (black) and with (red) microstimulation. X-axis, strength of RF stimulus; y-axis, firing rate. (B) Simulated responses for OTid unit #1 without and with AGF stimulation; AGF→OTid input gain parameter = 0.325, response gain parameter = 1.22; values chosen to show representative results, and correspond to the white ‘x’ in C. (C) Shift in s50 (%; left) and change in transition range (%; right) plotted as a function of input and response gain values (Experimental Procedures). Green arrow: largest magnitude of % change from simulation; red arrow: average % change from experiments.