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. Author manuscript; available in PMC: 2017 Jun 15.
Published in final edited form as: J Am Chem Soc. 2016 Jun 3;138(23):7411–7421. doi: 10.1021/jacs.6b03341

Scheme 2. Two Mechanistic Hypotheses for Aryl-amine Oxygenation Mediated by Diiron Cluster Enzymes.

Scheme 2

(I) Sequential three-oxidation mechanism requiring six external electrons (2 for each peroxo-intermediate) per turnover and (II) substrate-mediated reduction mechanism requiring a net of two external electrons per turnover because the diferrous cluster is regenerated at the end of the turnover cycle.