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. 2016 Mar 4;44(11):5105–5122. doi: 10.1093/nar/gkw113

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© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 8. — The transcriptional activity of pancNusap1-Nusap1 pair was regulated by Icer after cAMP stimulation. (A) pCreb1- and Icer-binding status at the Nusap1 promoter after 3, 24 and 72 h of NGF/cAMP treatment. Normal rabbit IgG (IgG) was used as a negative control. (B) The expression dynamics of pancNusap1 and Nusap1 after 2, 4, 24 and 72 h of NGF and/or cAMP treatment. (C and D) The effects of sh-Icer and sh-Creb OEs on the expression levels of their target genes (C) and the pancNusap1-Nusap1 pair (D) in NcAdiff cells. Viral vectors were introduced at day 3. In (A–D), values are mean ± SD (n = 3). Statistical analysis was performed using the Tukey-Kramer multiple comparison test. N.S. = not significant. *P < 0.05; **P < 0.01; ***P < 0.001.