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. 2016 Apr 7;44(11):5246–5255. doi: 10.1093/nar/gkw216

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© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Lysine 991 is required for the response to oxidative damage, but not for TC-NER. (A) Clonogenic survival assay, with percentage of surviving cells (logarithmic scale) plotted against UV dose. Error bars indicate the standard error of the mean from three independent experiments. (B) RNA synthesis recovery after UV-irradiation (5 J/m²), measured as the relative incorporation of ³H-uridine compared to non-irradiated cells (100%). Error bars indicate the standard error of the mean from three independent experiments. (C–E) Cell viability of CSB-/-, WT and CSB K991R cells after 3 days treatment with the indicated concentrations of cisplatin (C), potassium bromate (D) and paraquat (E). Error bars indicate standard error of the mean from three independent experiments.