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. 2016 Apr 7;44(11):5246–5255. doi: 10.1093/nar/gkw216

Figure 5.

Figure 5.

Recruitment of K991R and ΔUBD to sites of oxidative DNA damage. (A) Confocal microscopy images of GFP-tagged CSB K991R expressing cells before and after local induction of oxidative DNA damage (white circle). (B) Accumulation kinetics of relative fluorescence intensity (RFI) of WT and CSB K991R after local oxidative DNA damage (405nm with 5 μM Ro19-8022). (C) FRAP analysis of WT and CSB K991R in the absence and presence of oxidative DNA damage. The data of B and C represent the average fluorescence from 3 pooled, independent experiments with 15 cells each, error bars indicate the standard error of the mean of 45 cells.