Table 2. List of predicted interactions between nucleotides whose modification has been confirmed experimentally and the corresponding guide snoRNAs.
| Modified nucleotide | Currently assigned guide | Support by HTP | Newly predicted guide | Location of ASE | ICI | Conservation level of the snoRNA |
|---|---|---|---|---|---|---|
| 18S-683 | SNORD19 | - | SNORD136 | D' | 1.22 | Eutherians |
| 18S-1326 | SNORD33 | + | snoID_0337 | D' | 1.84 | Primates |
| 18S-1410 | NA | + | snoID_0340 | D | 1.33 | Primates |
| 18S-1606 | NA | + | SNORD73A/B | D' | 1.17 | Tetrapodes and Teleostes |
| 18S-681 | unknown | + | SNORA14A/B | 5′ stem | 0.84 | Amniotes |
| 18S-681 | unknown | + | SNORA55 | 3′ stem | 1.2 | Tetrapodes |
| 28S-4266 | unknown | - | SNORA78 | 5′ stem | 0.92 | Tetrapodes and Teleostes |
| 18S-1046 | NA | + | SNORA57 | 3′ stem | 0.9 | Deuterostomes |
| 18S-1232 | NA | + | SNORA70A/B/E/11/14 | 5′ stem | 1.18 | Vertebrates |
| 28S-2619 | NA | + | SNORA38A/B | 5′-stem | 0.84 | Therians |
The modification data originated either from snoRNAbase (https://www-snorna.biotoul.fr/), in which case guide snoRNAs were sometimes already assigned, or from the high-throughput (HTP) approaches, in which case the guiding snoRNAs were not known so far. We further provide the location of the ASE which is predicted to take part in the interaction, the Interaction Conservation Index (ICI) of the interaction and the conservation level of the predicted snoRNA guide.