Figure 6.

The substrate processing is generally unaffected by the distinctive cellular distribution pattern of endogenous Drosha splice variants. (A) Relative expression ratio of mature miRNAs over pri-miRNAs in log₂ scale normalized to snRNA U6 or cyclophilin A, respectively. (B) Relative expression of a fragment located upstream (ctrl) to the region including the cleavage site normalized to cyclophilin A. Ctrl = control. Statistical significance calculated with student's t-test, performed for normalized values: *P < 0.05; **P < 0.01; ***P < 0.001. N = 3. Error bars indicate SEM.