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. 2016 May 10;44(11):5356–5364. doi: 10.1093/nar/gkw405

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© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — Cre-ER^T-dependent activation of type-I IFN gene signatures. (A) Microarray analysis of MEFs (48 h post-initial OHT treatment for Dicer^wt/wt × Cre/ESR1⁺ and Cre/ESR1⁻ cells and 96 h for Dicer ^f/wt × Cre/ESR1⁺and Dicer ^f/f cells), restricted to 23 ISGs. NT: non-treated. (B) RT-qPCR analysis of ISGs in MEFs after 24 h OHT treatment. Data are shown relative to non-treated Cre/ESR1⁻ cells (data are presented as mean of three independent experiments in biological duplicate ± s.e.m.). (C) Dose-response study of varying concentrations of OHT on MEFs, on the levels of Viperin and p56, 72 h after stimulation. (B and C) Data shown are representative of three independent experiments.