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. 2015 Nov 20;1(10):e44. doi: 10.1097/TXD.0000000000000551

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Copyright © 2015 The Authors. Transplantation Direct. Published by Wolters Kluwer Health, Inc.

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/3.0.

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Functional enrichment analysis of ACR-associated microRNA gene targets. A, Differentially expressed microRNAs in airway epithelium of patients with ACR were linked to 253 experimentally verified gene products, creating a complex interaction network (see also Figure 2). Note that some microRNAs, such as miR-34a-5p and miR-124-3p, modulated many targets, whereas others influenced very few genes. B, A representative summary of functional categories and pathways enriched among these 253 microRNA-regulated genes reveals that ACR is highlighted by activation of processes involved in proliferation, transformation, development, differentiation, repair, and migration.