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. 2016 May 31;113(24):E3451–E3460. doi: 10.1073/pnas.1506113113

Fig. 7.

Fig. 7.

Administration of thyroid hormones attenuates the acute hepatic response to CCl4 treatment in mice. (A) Scheme of the treatments (vehicle, n = 4; CCl4, n = 6). (B) Representative Masson’s trichrome staining of livers of the different experimental groups after acute CCl4 treatment, showing extensive damage with nuclei loss only in euthyroid animals. (Scale bar, 50 µm.) (C) AST activity in serum. Data are mean ± SEM. Significance of ANOVA posttest (Bonferroni) between euthyroid and hyperthyroid CCl4-treated mice is indicated. (D) Western blot of pSMAD2, pSMAD3, SMAD2/3, and SMAD4 in the livers after acute CCl4 treatment. ERK2 was used as a loading control. (Right) pSMAD2/SMAD2,3 and pSMAD3/SMAD2,3 ratios (mean ± SEM) were quantitated and are shown.