Figure 3. The Morris Water Maze task shows a mild deficit in accuracy of spatial long-term memory 4 month-old FDD_KI/Aph1BC^−/− mice.

Data are expressed as means ± S.E.M. A.-B. Performance on the visible platform task. The visible platform task indicates that there were no significant differences among the genotypes in path length traveled (A) or swim speed (B). C. Acquisition of spatial reference memory in the hidden platform task. Mean path lengths across 6 daily trials are shown. Significant differences among the genotypes were found only on the first day: * p < 0.05, ** p < 0.01, *** p < 0.001. D.-F. Performance on the 60-s probe trial given 2 days after the last acquisition session. (D-F) Performance on the 60-s probe trial given 2 days after the last acquisition session. (D) Percentage of time spent in the four quadrants. ** p < 0.01, *** p < 0.001, **** p < 0.0001 (E) Number of counter crossings in the target quadrant (Quadrant 4). * p < 0.05 (F) A separate unpaired t-test showed a significant difference between WT and FDD_KI/Aph1BC^−/− mice (* p = 0.0177). G. Average proximity to the former platform location. H. Performance in the reversal learning task with a new platform location. Mean path length across 6 daily trials are shown. I.-K. Performance on the 60-s probe trail given 2 days after the last reversal learning session. (I) Percentage of time spent in the four quadrants. **** p < 0.0001 (J) Number of counter crossings in the target quadrant (Quadrant 1). (K) Average proximity to the former platform location.