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. 2016 Feb 23;7(11):12063–12074. doi: 10.18632/oncotarget.7642

Figure 5. GDF11 induces AMPK activation which is inhibited by mitoTEMPO.

Figure 5

A. GDF11 increased the protein level of p-AMPK after GDF11 treatment (50ng/ml) for 48h in HUVECs. **P < 0.01 vs. control. n = 8. B. MitoTEMPO inhibited GDF11-induced MAPK activation in HUVECs. The cells were pre-treated with mitoTEMPO(25nM) for 1h and then GDF11(50ng/ml) was added. **P < 0.01 vs. control.# P < 0.05 vs. GDF11 treatment group. n = 5.