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. 2016 Mar 2;7(11):12150–12162. doi: 10.18632/oncotarget.7859

Figure 9. Overexpression of PGC-1α in podocytes blocked Aldo-induced podocyte phenotypic changes.

Figure 9

Cells were grown on 6-well plates until 30% confluence, transfected with Lentivirus expressing PGC-1α or mutant plasmid for 24 h, and then treated with Aldo (200 μmol/l) for another 24 h. A. Western blotting analysis of PGC-1α. B. Western blotting analysis for α3-integrin, Upper: representative immunoblots. Lower: densitometric analysis. C. Cell adhesion analysis. D. Western blotting analysis for MMP-9, α-SMA, desmin, P-cadherin, nephrin, Upper: representative immunoblots. Lower: densitometric analysis. The results are presented as means ± SE (n = 4). *P < 0.05 vs. vehi group. #P < 0.01 vs. Aldo group. ΔP < 0.05 vs. PGC-1α overexpression group.