Table 1. Potential strategies for CRISPR/Cas9 interventions targeting cellular genes in cancer.

Gene Type	Family Example	Gene	Function	Approach	Gene Reference
Oncogene	Receptor tyrosine kinase	ErbB	Tyrosine kinase	Disrupt or mutate	48, 58
	Nonreceptor	src, abl, fps, yes,	Tyrosine kinase	Disrupt or mutate	49
	G proteins	ras	Molecular Switch	Disrupt or mutate	50
	Signaling kinase	raf	Serine/threonine kinase	Disrupt or mutate	51
	Transcription regulator	myc	Transcription factor	Disrupt or mutate	52
Tumor Suppressor	Pocket protein	pRb	Cell cycle regulator	Repair	78-80
	Gene Regulation	p53	Transcription	Repair	81
	Signal regulation	PTEN	Protein phosphatase	Repair	82
	DNA repair	BRCA1/2	DNA repair	Repair	83, 84
	DNA damage checkpoint	ATM	Serine/threonine kinase	Repair	85
Epigenetic Conrol loci	DNMTs	DNMT1	DNA methyltransferase	Repair	101
	Histone modification	EZH2/	Histone methylase demethylase	Repair	103, 104
Chemo-resistance	Efflux pumps	MDR-1 MRP	ABC transporter	Repair	107, 108
	Drug metabolism	GST-p	GSH conjugation	Repair	111
		Cytokine P450	Inactivation	Repair	112
		UGT1A1	Gluconylation	Repair	113