Table 2. Strategies for CRISPR/Cas9 interventions targeting viral cellular genes in cancer.
| Gene type | Virus | Family | Gene | Function | Approach | Reference |
|---|---|---|---|---|---|---|
| Oncogene | Hepatitis B | Hepadna-virus | Various | Disruption | 62-64, 68, 70 | |
| S | Surface antigen | Disruption | 65, 67 | |||
| Signal transduction | Disruption | 65, 67 | ||||
| Core, P, | Viral capsid | Disruption | 69 | |||
| DNA polymerase | Disruption | 69 | ||||
| X | Signal transduction | Disruption | 69 | |||
| Epstein-Barr | Herpes-virus | Various | Disruption | 75 | ||
| BART | MicroRNAs | Disruption | 76 | |||
| Tumor Suppressor Inactivators | HPV16/18 | Papilloma-virus | E6 | p53 inactivator | Disruption | 93, 95 |
| E7 | pRb Inactivator | Disruption | 93-95 | |||
| JCPyV | Polyoma-virus | T-antigen | p53 and pRb inactivator | Disruption | 30 | |
| Hepatitis B | Hepadna-virus | HBx | p53 inactivator | Disruption | 65, 67, 69 |