Figure 4. ER stress is involved in XCT-790 induced apoptosis.

MDA-MB-231 (A) or BT-549 (B) cells were treated with 5 μM XCT-790 for the indicated times, and then the expression of ATF4, ATF6, XBP-1 and CHOP were determined by Western blot analysis; (C) MDA-MB-231 cells were transfected with siNC or si-ERRα for 48 h, and then the ER-stress related proteins were measured by Western blot analysis.