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. 2016 Feb 9;7(11):12633–12650. doi: 10.18632/oncotarget.7279

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Copyright: © 2016 Yuan et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Volcano plots comparing the DNA methylation between parathyroid tumor samples and controls are on the x-axis and the −log2 of the corresponding P values of those mean differences are on the y-axis (A–C). The green dots represent significantly hypermethylated loci whereas the red dots represent hypomethylated ones. Loci in MEN1-parathyroid tumor cases are significantly more methylated when compared to normal parathyroid tissues (A). Hierarchical Cluster showing high correlation of methylated loci in the MEN1 group (*: single sporadic adenoma that segregated with the MEN1 group; Ad: parathyroid adenoma; Ca: parathyroid carcinoma; M: MEN1-parathyroid tumor; N: Normal parathyroid tissues) (D). Circular heatmap representation of DNA methylation levels for parathyroid adenoma (Adenoma), parathyroid carcinoma (Cancer), MEN1-parathyroid tumors (MEN1), and normal parathyroid (Normal) (E). DNA methylation levels from each patient were averaged in 10 Mbp genomic windows. The heatmap indicates global DNA hypermethylation in MEN1 patients.