Figure 4. Increased enzymatic activity of DNMT1 in endocrine tumors from human MEN1 parathyroids and Men1 KO mice.

DNMT1 enzymatic activity was significantly increased in the parathyroid tumor tissues from MEN1 patients (A) and mouse pancreatic endocrine tumors (B) from Men1 KO mice compared to normal endocrine tissues from humans and control mice by a functional DNMT1 assay. (Normal: human normal parathyroids; MEN1: human MEN1 parathyroids; KO: Men1 KO mice; WT: Men1 WT mice). (***P < 0.001).