Table 3. Clinicopathological and molecular features of 152 serrated lesions and 55 non-serrated adenomas.
| Clinicopathological or molecular feature | Total N | Histological type | p | |||
|---|---|---|---|---|---|---|
| Hyperplastic polyp (HP) | Sessile serrated adenoma/polyp (SSA/P) | Traditional serrated adenoma (TSA) | Non-serrated adenoma | |||
| All cases | 207 | 50 | 51 | 51 | 55 | |
| Gender | ||||||
| Male | 124 (60%) | 36 (72%) | 23 (45%) | 26 (51%) | 39 (71%) | 0.0065 |
| Female | 83 (40%) | 14 (28%) | 28 (55%) | 25 (49%) | 16 (29%) | |
| Age (mean ± SD) | 61.7 ± 10.8 | 58.9 ± 11.6 | 57.4 ± 10.8 | 65.1 ± 11.5 | 65.3 ± 8.7 | < 0.0001 |
| Tumor size (mm) (mean ± SD) | 11.0 ± 5.3 | 9.0 ± 3.7 | 13.5 ± 6.7 | 9.9 ± 4.7 | 11.4 ± 5.4 | 0.0002 |
| Tumor location | ||||||
| Rectum and Distal colon | 98 (47%) | 24 (48%) | 5 (9.8%) | 38 (75%) | 31 (56%) | < 0.0001 |
| Proximal colon | 109 (53%) | 26 (52%) | 46 (90%) | 13 (25%) | 24 (44%) | |
| BRAF mutation | ||||||
| Wild-type | 107 (52%) | 27 (54%) | 7 (14%) | 19 (37%) | 54 (98%) | < 0.0001 |
| Mutant | 100 (48%) | 23 (46%) | 44 (86%) | 32 (63%) | 1 (1.8%) | |
| CIMP status | ||||||
| CIMP-low/zero | 174 (84%) | 46 (92%) | 32 (63%) | 41 (80%) | 55 (100%) | < 0.0001 |
| CIMP-high | 33 (16%) | 4 (8.0%) | 19 (37%) | 10 (20%) | 0 (0%) | |
| MicroRNA-31 | ||||||
| Low expression (Q1-3) | 155 (75%) | 39 (78%) | 40 (78%) | 27 (53%) | 49 (89%) | < 0.0001 |
| High expression (Q4) | 52 (25%) | 11 (22%) | 11 (22%) | 24 (47%) | 6 (11%) | |
| EZH2 expression | ||||||
| Score 0 (negative) | 90 (43%) | 18 (36%) | 39 (76%) | 13 (25%) | 20 (36%) | < 0.0001 |
| Score 1 (weak) | 83 (40%) | 20 (40%) | 12 (24%) | 23 (45%) | 28 (51%) | |
| Score 2 (moderate) | 34 (16%) | 12 (24%) | 0 (0%) | 15 (29%) | 7 (13%) | |
| Score 3 (strong) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | |
P-values were calculated by analysis of variance for age and tumor size, and by a chi-square test for all other variables. CIMP, CpG island methylator phenotype; HP, hyperplastic polyp; SSA/P, sessile serrated adenoma/polyp; SD, standard deviation; TSA, traditional serrated adenoma.