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. 2016 Feb 7;7(11):12783–12790. doi: 10.18632/oncotarget.7226

Figure 1. Treatment model and protocol.

Figure 1

A. Soft tissue sarcoma PDOX mouse model. Ten days after surgical orthotopic implantation (SOI), tumors in the right biceps femoris muscle had grown more than 5 mm in diameter. Arrow indicates a grown tumor. Scale bar: 10 mm. B. Treatment protocol. G1: untreated control; G2: treated with S. typhimurium A1-R (A1-R)-alone (i.t., 5 × 107 CFU/body, weekly, 4 weeks) G3: treated with doxorubicin (DOX)-alone (i.p., 3 mg/kg, weekly, 4 weeks); G4: treated with S. typhimurium A1-R (i.t., 5 × 107 CFU/body, weekly, 2 weeks) followed by DOX (i.p., 3 mg/kg, weekly, 2 weeks). Each group contained 5 mice.