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. 2016 Feb 7;7(11):12806–12822. doi: 10.18632/oncotarget.7230

Figure 8. Stability and in vivo distribution of FITC-RTX/GO made from non-sonicated or sonicated/filtered GO: Non-sonicated or sonicated/filtered GO was mixed with human serum (10 μg/ml) and the GO serum dispersions were monitored for 21 days.

Figure 8

Non-sonicated GO precipitated in four hours whereas sonicated/filtered GO remained in dispersion at least by day 21 A. RTX/GO made of either non-sonicated or sonicated/filtered GO with RTX-FITC was injected into NRG mice iv and organs were sampled 2 hours after injection. Fluorescence microscopy shows the distribution of FITC-RTX/GO in the lung and liver. The images were taken using EVOS Cell Imaging System, (AMF-4301), with scale bar showing 400 μ. The location of fluorescence derived FITC-RTX/GO made of sonicated/filtered GO in the liver is consistent with location of Kupffer cells B.