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. 2016 Feb 12;7(11):12893–12903. doi: 10.18632/oncotarget.7335

Figure 4. MLN-8237 induces differential effect in a dose dependent manner.

Figure 4

HCT116 cells transfected with GFP-histone 2B for 24 h were treated with 0.1 (A) or 1 μM (B) MLN-8237 and live cell imaging was done after 18 h of exposure as described in Materials and Methods. Shown are selected still images from time-lapse movies; the fate of individual cells was tracked over time. (A) Cells exposed to 0.1 μM MLN-8237 enter mitosis; stays many hours followed by apoptosis (in white circle, 30%) (Supplementary Video 1A data). (B) Cells exposed to 1 μM MLN-8237 enter mitosis after a short delay undergoes endoreduplication results in polyploidy (in red circle, 60%) (Supplementary Video 1B data).