Table 1A. Mean intensities and variations of the most significant metabolites found in the comparison between healthy individuals and NSCLC patients.

Metabolite	δ 1H (ppm)a	Mean spectral intensity ± s.e.m. (arbitrary units)		% variation	P-valueb
		Healthy Group	NSCLC patients
HDL (CH3)	0.85-0.79	55.14 ± 1.50	45.55 ± 0.73	−17.39	0.0000*
VLDL (CH3)	0.91-0.85	66.10 ± 1.49	65.17 ± 0.78	−1.40	0.9070
Leucine/Isoleucine	0.97-0.91	14.40 ± 0.25	16.67 ± 0.26	15.75	0.0000*
3-hydroxybutyrate	1.20-1.18	8.22 ± 0.15	8.60 ± 0.20	4.59	0.8585
LDL/VLDL (CH2)n	1.31-1.20	229.06 ± 6.10	197.77 ± 3.26	−13.66	0.0001*
Unknown 1	1.40-1.36	4.01 ± 0.11	5.04 ± 0.14	25.65	0.0000*
Adipic acid	1.60-1.52	15.97 ± 0.69	13.79 ± 0.34	−13.64	0.0406*
Acetate	1.91-1.90	1.29 ± 0.04	1.56 ± 0.04	21.22	0.0001*
Lipids (CH2-C=C)	2.02-1.93	40.15 ± 0.46	35.56 ± 0.31	−11.44	0.0000*
N-Acetyl-cysteine	2.05-2.02	23.50 ± 0.32	27.01 ± 0.44	14.94	0.0000*
Lipids (CH2-CO)	2.26-2.19	14.19 ± 0.65	13.17 ± 0.30	−7.15	0.5775
Glutamate	2.36-2.33	2.14 ± 0.07	2.95 ± 0.07	37.65	0.0000*
Glutamine	2.47-2.41	5.82 ± 0.19	4.98 ± 0.11	−14.37	0.0002*
Choline–N(CH3)3+	3.21-3.18	23.56 ± 0.67	17.60 ± 0.34	−25.30	0.0000*
Methanol	3.36-3.35	1.01 ± 0.05	1.81 ± 0.05	78.81	0.0000*
Glycerol	3.80-3.78	2.90 ± 0.09	3.63 ± 0.08	25.16	0.0000*
Creatine	3.92-3.91	0.90 ± 0.04	1.20 ± 0.03	33.82	0.0000*
Lactate	4.13-4.08	10.45 ± 0.38	13.74 ± 0.42	31.53	0.0000*
Threonine	4.30-4.21	6.92 ± 0.12	5.86 ± 0.09	−15.34	0.0000*
Glucose	5.24-5.21	11.92 ± 0.35	12.63 ± 0.26	5.92	0.2202
Lipids (CH=CH)	5.37-5.24	32.92 ± 0.75	28.08 ± 0.45	−14.70	0.0000*
Histidine	7.78-7.74	0.37 ± 0.01	0.29 ± 0.01	−20.76	0.0000*

^aChemical shift region used for quantification

^bP-value calculated using the Mann–Whitney-Wilcoxon test

^*Statistically significant (P < 0.05)