Table 1B. Mean intensities and variations of the most significant metabolites found in the comparison between earlystage and advanced-stage NSCLC patients.
Metabolites | δ 1H (ppm)a | Mean spectral intensity ± s.e.m. (arbitrary units) | % variation | P-valueb | |
---|---|---|---|---|---|
ES/NSCLC | AS/NSCLC | ||||
HDL (CH3) | 0.85-0.79 | 45.72 ± 1.08 | 45.70±1.01 | −0.06 | 0.9054 |
VLDL (CH3) | 0.91-0.85 | 65.66 ± 0.94 | 64.71 ± 1.23 | −1.43 | 0.8602 |
Leucine/Isoleucine | 0.97-0.91 | 15.89 ± 0.34 | 17.41 ±0.37 | 9.59 | 0.0039* |
3-hydroxybutyrate | 1.20-1.18 | 9.38 ± 0.31 | 7.85 ± 0.21 | −16.26 | 0.0000* |
LDL/VLDL (CH2)n | 1.31-1.20 | 203.92 ± 4.48 | 191.89 ± 4.65 | −5.90 | 0.1151 |
Adipic acid | 1.60-1.52 | 14.61 ± 0.50 | 13.00 ± 0.44 | −11.01 | 0.0248* |
Lysine | 1.75-1.65 | 9.15 ± 0.26 | 10.36 ± 0.26 | 13.16 | 0.0025* |
Lipids (CH2-C=C) | 2.02-1.93 | 35.27 ± 0.40 | 35.84 ±0.48 | 1.60 | 0.1403 |
N-Acetyl-cysteine | 2.05-2.02 | 24.51 ± 0.50 | 29.39 ± 0.59 | 19.90 | 0.0000* |
Glutamate | 2.09-2.05 | 10.09 ± 0.24 | 12.30 ± 0.27 | 21.86 | 0.0000* |
Lipids (CH2-CO) | 2.26-2.19 | 14.55 ± 0.42 | 11.85 ± 0.37 | −18.54 | 0.0000* |
Glutamine | 2.47-2.41 | 5.91 ± 0.17 | 5.03 ± 0.15 | −14.84 | 0.0005* |
Citrate | 2.96-2.64 | 4.66 ± 0.11 | 5.41 ± 0.11 | 16.26 | 0.0000* |
Choline–N(CH3)3+ | 3.21-3.18 | 18.05 ± 0.50 | 17.17 ± 0.46 | −4.86 | 0.2081 |
Unknown 2 | 3.55-3.54 | 3.22 ± 0.09 | 3.40 ± 0.09 | 5.76 | 0.1852 |
Unknown 3 | 3.58-3.56 | 4.98 ± 0.17 | 5.97 ± 0.16 | 19.71 | 0.0000* |
Valine | 3.61-3.59 | 3.55 ± 0.10 | 4.30 ± 0.10 | 21.05 | 0.0000* |
Glycerol | 3.67-3.63 | 13.49 ± 0.38 | 15.76 ± 0.38 | 16.82 | 0.0001* |
Creatine | 3.92-3.91 | 1.25 ± 0.04 | 1.43 ± 0.04 | 14.43 | 0.0031* |
H α/β amino acids | 4.02-3.92 | 8.86 ± 0.26 | 10.54 ± 0.27 | 18.92 | 0.0000* |
Lactate | 4.13-4.08 | 13.01 ± 0.52 | 14.59 ± 0.64 | 12.15 | 0.0274* |
Glucose | 5.24-5.21 | 13.06 ± 0.37 | 11.86 ± 0.37 | −9.19 | 0.0058* |
Lipids (CH=CH) | 5.37-5.24 | 28.89 ± 0.58 | 27.51 ± 0.70 | −4.79 | 0.2948 |
Phenylalanine | 7.43-7.40 | 0.31 ± 0.02 | 0.47 ± 0.03 | 52.10 | 0.0000* |
Chemical shift region used for quantification
P-value calculated using the Mann–Whitney-Wilcoxon test
Statistically significant (P < 0.05)