Table 1B. Mean intensities and variations of the most significant metabolites found in the comparison between earlystage and advanced-stage NSCLC patients.

Metabolites	δ 1H (ppm)a	Mean spectral intensity ± s.e.m. (arbitrary units)		% variation	P-valueb
		ES/NSCLC	AS/NSCLC
HDL (CH3)	0.85-0.79	45.72 ± 1.08	45.70±1.01	−0.06	0.9054
VLDL (CH3)	0.91-0.85	65.66 ± 0.94	64.71 ± 1.23	−1.43	0.8602
Leucine/Isoleucine	0.97-0.91	15.89 ± 0.34	17.41 ±0.37	9.59	0.0039*
3-hydroxybutyrate	1.20-1.18	9.38 ± 0.31	7.85 ± 0.21	−16.26	0.0000*
LDL/VLDL (CH2)n	1.31-1.20	203.92 ± 4.48	191.89 ± 4.65	−5.90	0.1151
Adipic acid	1.60-1.52	14.61 ± 0.50	13.00 ± 0.44	−11.01	0.0248*
Lysine	1.75-1.65	9.15 ± 0.26	10.36 ± 0.26	13.16	0.0025*
Lipids (CH2-C=C)	2.02-1.93	35.27 ± 0.40	35.84 ±0.48	1.60	0.1403
N-Acetyl-cysteine	2.05-2.02	24.51 ± 0.50	29.39 ± 0.59	19.90	0.0000*
Glutamate	2.09-2.05	10.09 ± 0.24	12.30 ± 0.27	21.86	0.0000*
Lipids (CH2-CO)	2.26-2.19	14.55 ± 0.42	11.85 ± 0.37	−18.54	0.0000*
Glutamine	2.47-2.41	5.91 ± 0.17	5.03 ± 0.15	−14.84	0.0005*
Citrate	2.96-2.64	4.66 ± 0.11	5.41 ± 0.11	16.26	0.0000*
Choline–N(CH3)3+	3.21-3.18	18.05 ± 0.50	17.17 ± 0.46	−4.86	0.2081
Unknown 2	3.55-3.54	3.22 ± 0.09	3.40 ± 0.09	5.76	0.1852
Unknown 3	3.58-3.56	4.98 ± 0.17	5.97 ± 0.16	19.71	0.0000*
Valine	3.61-3.59	3.55 ± 0.10	4.30 ± 0.10	21.05	0.0000*
Glycerol	3.67-3.63	13.49 ± 0.38	15.76 ± 0.38	16.82	0.0001*
Creatine	3.92-3.91	1.25 ± 0.04	1.43 ± 0.04	14.43	0.0031*
H α/β amino acids	4.02-3.92	8.86 ± 0.26	10.54 ± 0.27	18.92	0.0000*
Lactate	4.13-4.08	13.01 ± 0.52	14.59 ± 0.64	12.15	0.0274*
Glucose	5.24-5.21	13.06 ± 0.37	11.86 ± 0.37	−9.19	0.0058*
Lipids (CH=CH)	5.37-5.24	28.89 ± 0.58	27.51 ± 0.70	−4.79	0.2948
Phenylalanine	7.43-7.40	0.31 ± 0.02	0.47 ± 0.03	52.10	0.0000*

^aChemical shift region used for quantification

^bP-value calculated using the Mann–Whitney-Wilcoxon test

^*Statistically significant (P < 0.05)