Table 3. Variations of the mean intensities of the most relevant metabolites involved in the discrimination between BPD patients and healthy individuals or NSCLC patients.

Metabolites	δ1H (ppm)a	BPD vs. Healthy		BPD vs. NSCLC
		% variation	P-valueb	% variation	P-valueb
HDL (CH3)	0.85-0.79	−6.55	0.3602	−9.37	0.1073
VLDL (CH3)	0.91-0.85	−0.19	0.7539	−16.47	0.0002*
Leucine/Isoleucine	0.97-0.91	2.52	0.9319	8.54	0.0360*
3-hydroxybutyrate	1.20-1.18	−2.98	0.5490	20.64	0.0735
LDL/VLDL (CH2)n	1.31-1.20	1.61	0.9319	−23.28	0.0000*
Unknown 1	1.40-1.36	34.21	0.1424	−7.80	0.0676
Adipic acid	1.60-1.52	4.30	0.8867	−28.57	0.0001*
Acetate	1.91-1.90	−15.53	0.7979	6.96	0.0078*
Lipids (CH2-C=C)	2.02-1.93	−6.28	0.1424	−15.00	0.0000*
N-Acetyl-cysteine	2.05-2.02	−8.02	0.0392*	−6.80	0.0152*
Lipids (CH2-CO)	2.26-2.19	4.63	0.8867	−12.33	0.1674
Glutamate	2.36-2.33	−7.84	0.2175	43.35	0.0000*
Glutamine	2.47-2.41	−15.34	0.1065	−14.08	0.0136*
Lipids (CH=CH-CH2-CH=CH)	2.79-2.68	−0.06	0.6077	−15.40	0.0000*
Choline –N(CH3)3+	3.21-3.18	−3.46	0.8197	−14.45	0.0461*
Proline	3.30-3.34	−27.10	0.0130*	−15.46	0.0434*
Methanol	3.36-3.35	−45.45	0.0010*	−34.12	0.0002*
Unknown 2	3.55-3.54	−10.03	0.3166	17.93	0.0091*
Unknown 3	3.58-3.56	−13.86	0.2765	9.10	0.1714
Valine	3.61-3.59	−11.64	0.2068	9.14	0.2150
Glycerol	3.80-3.78	−7.20	0.4406	17.94	0.0027*
Creatine	3.92-3.91	−12.39	0.2175	22.52	0.0005*
Creatinine	4.04-4.03	−0.24	0.6898	−24.18	0.0000*
Myo-inositol	4.07-4.05	10.28	0.4578	−33.58	0.0000*
Lactate	4.13-4.08	49.44	0.0002*	16.92	0.0136*
Threonine	4.30-4.21	4.85	0.5878	−26.09	0.0000*
Glucose	5.24-5.21	−5.59	0.2639	42.78	0.0000*
Lipids (CH=CH)	5.37-5.24	2.23	0.3602	−21.01	0.0000*

^aChemical shift region used for quantification

^bP-value calculated using the Mann–Whitney U test

^*Statistically significant (P < 0.05)