Table 3. Variations of the mean intensities of the most relevant metabolites involved in the discrimination between BPD patients and healthy individuals or NSCLC patients.
Metabolites | δ1H (ppm)a | BPD vs. Healthy | BPD vs. NSCLC | ||
---|---|---|---|---|---|
% variation | P-valueb | % variation | P-valueb | ||
HDL (CH3) | 0.85-0.79 | −6.55 | 0.3602 | −9.37 | 0.1073 |
VLDL (CH3) | 0.91-0.85 | −0.19 | 0.7539 | −16.47 | 0.0002* |
Leucine/Isoleucine | 0.97-0.91 | 2.52 | 0.9319 | 8.54 | 0.0360* |
3-hydroxybutyrate | 1.20-1.18 | −2.98 | 0.5490 | 20.64 | 0.0735 |
LDL/VLDL (CH2)n | 1.31-1.20 | 1.61 | 0.9319 | −23.28 | 0.0000* |
Unknown 1 | 1.40-1.36 | 34.21 | 0.1424 | −7.80 | 0.0676 |
Adipic acid | 1.60-1.52 | 4.30 | 0.8867 | −28.57 | 0.0001* |
Acetate | 1.91-1.90 | −15.53 | 0.7979 | 6.96 | 0.0078* |
Lipids (CH2-C=C) | 2.02-1.93 | −6.28 | 0.1424 | −15.00 | 0.0000* |
N-Acetyl-cysteine | 2.05-2.02 | −8.02 | 0.0392* | −6.80 | 0.0152* |
Lipids (CH2-CO) | 2.26-2.19 | 4.63 | 0.8867 | −12.33 | 0.1674 |
Glutamate | 2.36-2.33 | −7.84 | 0.2175 | 43.35 | 0.0000* |
Glutamine | 2.47-2.41 | −15.34 | 0.1065 | −14.08 | 0.0136* |
Lipids (CH=CH-CH2-CH=CH) | 2.79-2.68 | −0.06 | 0.6077 | −15.40 | 0.0000* |
Choline –N(CH3)3+ | 3.21-3.18 | −3.46 | 0.8197 | −14.45 | 0.0461* |
Proline | 3.30-3.34 | −27.10 | 0.0130* | −15.46 | 0.0434* |
Methanol | 3.36-3.35 | −45.45 | 0.0010* | −34.12 | 0.0002* |
Unknown 2 | 3.55-3.54 | −10.03 | 0.3166 | 17.93 | 0.0091* |
Unknown 3 | 3.58-3.56 | −13.86 | 0.2765 | 9.10 | 0.1714 |
Valine | 3.61-3.59 | −11.64 | 0.2068 | 9.14 | 0.2150 |
Glycerol | 3.80-3.78 | −7.20 | 0.4406 | 17.94 | 0.0027* |
Creatine | 3.92-3.91 | −12.39 | 0.2175 | 22.52 | 0.0005* |
Creatinine | 4.04-4.03 | −0.24 | 0.6898 | −24.18 | 0.0000* |
Myo-inositol | 4.07-4.05 | 10.28 | 0.4578 | −33.58 | 0.0000* |
Lactate | 4.13-4.08 | 49.44 | 0.0002* | 16.92 | 0.0136* |
Threonine | 4.30-4.21 | 4.85 | 0.5878 | −26.09 | 0.0000* |
Glucose | 5.24-5.21 | −5.59 | 0.2639 | 42.78 | 0.0000* |
Lipids (CH=CH) | 5.37-5.24 | 2.23 | 0.3602 | −21.01 | 0.0000* |
Chemical shift region used for quantification
P-value calculated using the Mann–Whitney U test
Statistically significant (P < 0.05)