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. 2016 Feb 11;7(11):12917–12926. doi: 10.18632/oncotarget.7338

Figure 1. LY5, a novel STAT3 inhibitor decreased constitutive phosphorylation of STAT3 in colon cancer cells.

Figure 1

(A) Chemical structure of LY5. (B) and (C) The docking mode of LY5 and STAT3 crystal structure (PDB:1BG1). LY5 can bind to the pTyr705 and side pocket sites. (D) LY5 and LLL12 (1.0, 2.5, and 5 μM) inhibited STAT3 phosphorylation and induce apoptosis in HCT116 colon cancer cells. (E) LY5 (1.0, 2.5, and 5 μM) inhibited STAT3 phosphorylation and induced cell apoptosis in SW480 and DLD1 human colon cancer cells.