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. 2016 Feb 11;7(11):12917–12926. doi: 10.18632/oncotarget.7338

Figure 3. LY5 inhibited STAT3 phosphorylation induced by IL-6.

Figure 3

LY5 inhibited STAT3 phosphorylation induced by IL-6 in (A) DLD1 colon cancer and (B) Hep3B liver cancer cells. LY5 did not inhibit STAT1 phosphorylation induced by IFN-γ in (C) DLD1 colon cancer and (D) Hep3B liver cancer cells. After 2 hours of LY5 pre-treatment, cells were stimulated by IL-6 (50 ng/mL) or IFN-γ (50 ng/mL) for 30 mins. The cells were harvested and analyzed for STAT3 and STAT1 phosphorylation by western blot as described in Materials and Methods.