Table 2.

Enzyme inhibition and antimycobacterial activity of 6a–f.

Inhibitor	R	appKi (nM)a	MIC (μM)b
2	nac	6.6 ± 1.5d	0.39d
3	nac	0.27 ± 0.07d	0.049d
6a		8.4 ± 1.0	25
6b		16.9 ± 1.9	25
6c		13.7 ± 2.3	19
6d		25.0 ± 1.9	>50
6e		6.1 ± 0.7	12.5
6f		10.5 ± 1.2	19

^aAssay performed with 7 nM MbtA, 10 mM ATP, 250 μM salicylic acid, 1 mM PPi.

^bM. tuberculosis H37Rv grown in glycerol-alanine salts (GAS) medium without ferric ammonium citrate at pH 6.6.

^cnot applicable.

^dreference 14.