(A) HT-29 cells exhibit rapamycin-induced feedback phosphorylation of Akt, but do not stabilize GATA6. a.u., arbitrary units. (B) AC16 cells exhibit stabilization of GATA6S, but not GATA6L, without rapamycin-induced feedback phosphorylation of Akt. Vinculin,, tubulin, and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) used as loading controls (51). Quantitative immunoblot data are means ± SEM of n = 4 biological replicates across two separate experiments.