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. Author manuscript; available in PMC: 2016 Aug 2.
Published in final edited form as: Mol Psychiatry. 2016 Feb 2;21(7):956–968. doi: 10.1038/mp.2015.222

Figure 1.

Figure 1

Decreased sIPSC frequency and amplitude and mIPSC frequency in mPFC pyramidal cells from adult MIA offspring. (A) Example traces showing sIPSCs recorded using a KCl-based intracellular solution in gap-free mode at a holding potential of −70 mV from pyramidal cells from adult Saline or MIA offspring with 20 μM CNQX and 50 μM AP5 in the bath. (B) The frequency and amplitude of sIPSCs were decreased in MIA offspring. (C) Example traces showing mIPSCs recorded using a KCl-based intracellular solution in gap-free mode at a holding potential of −70 mV from pyramidal cells from adult Saline or MIA offspring with 20 μM CNQX, 50 μM AP5 and 2 μM TTX in the bath. (D) The frequency, but not the amplitude, of mIPSCs was decreased in MIA offspring. *p<0.05.