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. Author manuscript; available in PMC: 2016 Aug 2.
Published in final edited form as: Mol Psychiatry. 2016 Feb 2;21(7):956–968. doi: 10.1038/mp.2015.222

Figure 5.

Figure 5

mPFC PV interneuron dysfunction may mediate impaired attentional set shifting and increased innate anxiety-like behavior in adult MIA offspring. (A) Diagram of experimental set-up for the attentional set shifting task. Mice were tested on 2 consecutive days with the mice randomized to have the light ON during the set shifting portion of the task on the first day or the second day. (B) Mice expressing e-Arch3.0 in PV interneurons in the mPFC (PV-eArch3.0) require significantly more trials to complete the set shifting portion of the task when the light is ON then when it is OFF. Light has no effect on the mice expressing GFP in PV interneurons in the mPFC (PV-GFP) control group. (C) Representative traces of the path taken by PV-eArch3.0 mice when the light is ON or OFF during the EPM. (D) The ratio of the time spent in the open arms relative to the closed arms (normalized to the GFP Light OFF average) is decreased in the PV-eArch3.0 mice when the light is ON, relative to when it's OFF, in the EPM. (E) Light has no effect on total distance traveled in the EPM. (F) Mean gamma power (30-80 Hz) in the mPFC of adult MIA offspring exploring the EPM is unchanged relative to Saline offspring. (G) In adult Saline offspring, but not adult MIA offspring, mean gamma power in the mPFC correlates with open arm time in the EPM. *p<0.05. (See also Supplementary Figures S6 and S7).